abstract：:As a part of the serotoninergic dysfunction implicated in neurobiology of depression, evidence has focused on serotonin (5-HT) receptors downstream signaling intermediates including glycogen synthase kinase-3β (GSK-3β), cAMP response element binding protein (CREB) and brain derived neurotrophic factor (BDNF). Our team...

journal_title：Toxicology and applied pharmacology

authors： Abuelezz SA,Hendawy N,Magdy Y

更新日期：2018-02-01 00:00:00

abstract：:Carnosic acid (CA), a major bioactive component in rosemary extract, has many biological and pharmaceutical activities. Smad3 acetylation can regulate the transcription of type I α2 collagen (COL1A2), which is the major component of the extracellular matrix (ECM). The aim of the current study was to evaluate whether C...

journal_title：Toxicology and applied pharmacology

authors： Zhao Y,Shi X,Ding C,Feng D,Li Y,Hu Y,Wang L,Gao D,Tian X,Yao J

更新日期：2018-01-15 00:00:00

abstract：:Liver fibrosis results from chronic tissue damage and excessive regeneration with accumulation of extracellular matrix proteins; it is a precursor of liver cirrhosis and hepatocellular carcinoma. Liver fibrosis treatments are primarily directed at inflammation, with few options to combat fibrogenesis. Pirfenidone is a...

journal_title：Toxicology and applied pharmacology

authors： Seniutkin O,Furuya S,Luo YS,Cichocki JA,Fukushima H,Kato Y,Sugimoto H,Matsumoto T,Uehara T,Rusyn I

更新日期：2018-01-15 00:00:00

abstract：:Inorganic arsenic (iAs) is a known toxicant and carcinogen. Worldwide arsenic exposure has become a threat to human health. The severity of arsenic toxicity is strongly correlated with the speed of arsenic metabolism (methylation) and clearance. Furthermore, oxidative stress is recognized as a major mechanism for arse...

journal_title：Toxicology and applied pharmacology

authors： Wang H,Zhu J,Li L,Li Y,Lv H,Xu Y,Sun G,Pi J

更新日期：2017-12-15 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is characterized by a disturbed pulmonary redox balance associated with inflammation. To restore this balance, antioxidants are often suggested as therapy for IPF but previous clinical trials with these compounds and their precursors have not been successful in the clinic. The exoge...

journal_title：Toxicology and applied pharmacology

authors： Veith C,Drent M,Bast A,van Schooten FJ,Boots AW

更新日期：2017-12-01 00:00:00

abstract：:Protein phosphatase 2A (PP2A) is a serine-threonine phosphatase that regulates cell signaling pathways. Its inactivation is correlated with tumor malignancy, possibly due to the effects on cell differentiation and malignant cell transformation. Therefore, it has been noted that PP2A could be a promising target for can...

journal_title：Toxicology and applied pharmacology

authors： Ishii Y,Kuroda K,Matsushita K,Yokoo Y,Takasu S,Kijima A,Nohmi T,Ogawa K,Umemura T

更新日期：2017-12-01 00:00:00

abstract：:We previously found downregulation of ubiquitin-conjugating enzyme E2E 2 (UBE2E2) in GST-P-positive (+) proliferative lesions produced by tumor promotion from early hepatocarcinogenesis stages in rats. Here we investigated the role of UBE2E2 downregulation in preneoplastic lesions of the liver and other target organs ...

journal_title：Toxicology and applied pharmacology

authors： Mizukami S,Watanabe Y,Saegusa Y,Nakajima K,Ito Y,Masubuchi Y,Yoshida T,Shibutani M

更新日期：2017-11-01 00:00:00

abstract：:Excessive fetal glucocorticoid exposure has been linked to increased susceptibility to hypertension and cardiac diseases in the adult life, a process called fetal programming. The cardiac contribution to the hypertensive phenotype of glucocorticoid-programmed progeny is less known, therefore, we investigated in vitro ...

journal_title：Toxicology and applied pharmacology

authors： Kiguti LRA,Borges CS,Mueller A,Silva KP,Polo CM,Rosa JL,Silva PV,Missassi G,Valencise L,Kempinas WG,Pupo AS

更新日期：2017-11-01 00:00:00

abstract：:Baicalin is a major flavonoid compound purified from Scutellariae radix, which has been described as an herb in the Chinese Pharmacopoeia. Previous studies have suggested baicalin possessed extensive anti-inflammatory, anti-cancer, anti-viral properties. However, up to known, there have been no reports of safety and t...

journal_title：Toxicology and applied pharmacology

authors： Cai Y,Ma W,Xiao Y,Wu B,Li X,Liu F,Qiu J,Zhang G

更新日期：2017-10-15 00:00:00

abstract：:The prediction and understanding of acetaminophen (APAP)-induced liver injury (APAP-ILI) and the response to therapeutic interventions is complex. This is due in part to sensitivity and specificity limitations of currently used assessment techniques. Here we sought to determine the utility of integrating translational...

journal_title：Toxicology and applied pharmacology

authors： Brillant N,Elmasry M,Burton NC,Rodriguez JM,Sharkey JW,Fenwick S,Poptani H,Kitteringham NR,Goldring CE,Kipar A,Park BK,Antoine DJ

更新日期：2017-10-01 00:00:00

abstract：:A series of naturally occurring cardenolides that exhibit potent anti-transmissible gastroenteritis virus (TGEV) activity in swine testicular (ST) cells has been identified. In an immunofluorescence assay, these cardenolides were found to diminish the expressions of TGEV nucleocapsid and spike protein, which was used ...

journal_title：Toxicology and applied pharmacology

authors： Yang CW,Chang HY,Hsu HY,Lee YZ,Chang HS,Chen IS,Lee SJ

更新日期：2017-10-01 00:00:00

abstract：:Arsenic contamination of drinking water and food threatens the health of hundreds of millions of people worldwide by increasing the risk of numerous diseases. Arsenic exposure has been associated with infectious lung disease in epidemiological studies, but it is not yet understood how ingestion of low levels of arseni...

journal_title：Toxicology and applied pharmacology

authors： Goodale BC,Rayack EJ,Stanton BA

更新日期：2017-09-15 00:00:00

abstract：:Gene 33 (Mig6, ERRFI1) is an adaptor protein with multiple cellular functions. We recently reported that depletion of this protein promotes lung epithelial cell transformation induced by hexavalent chromium [Cr(VI)]. However, the early molecular events that mediate this process are not clear. In the present study, we ...

journal_title：Toxicology and applied pharmacology

authors： Park S,Zhang X,Li C,Yin C,Li J,Fallon JT,Huang W,Xu D

更新日期：2017-09-01 00:00:00

abstract：:Several novel mechanistic findings regarding to arsenic's pathogenesis has been reported and some of them suggest that the etiology of some arsenic induced diseases are due in part to heritable changes to the genome via epigenetic processes such as DNA methylation, histone maintenance, and mRNA expression. Recently, w...

journal_title：Toxicology and applied pharmacology

authors： Gonzalez-Cortes T,Recio-Vega R,Lantz RC,Chau BT

更新日期：2017-08-15 00:00:00

abstract：:Nanotechnology has the potential to make a beneficial impact on several agricultural, forestry, and environmental challenges, such as urbanization, energy constraints, and sustainable use of resources. However, new environmental and human health hazards may emerge from nano-enhanced applications. This raises concerns ...

journal_title：Toxicology and applied pharmacology

authors： Iavicoli I,Leso V,Beezhold DH,Shvedova AA

更新日期：2017-08-15 00:00:00

abstract：:Spontaneous activity represents an early, primitive form of motor activity within zebrafish embryos, providing a potential readout for identification of neuroactive compounds. However, despite use as an endpoint in chemical screens around the world, the predictive power and limitations of assays relying on spontaneous...

journal_title：Toxicology and applied pharmacology

authors： Vliet SM,Ho TC,Volz DC

更新日期：2017-08-15 00:00:00

abstract：:Activation of Nrf2 with sulforaphane has recently gained attention as a new therapeutic approach in the treatment of many diseases, including epilepsy. As a plant-derived compound, sulforaphane is considered to be safe and well-tolerated. It is widely consumed, also by patients suffering from seizure and taking antiep...

journal_title：Toxicology and applied pharmacology

authors： Socała K,Nieoczym D,Kowalczuk-Vasilev E,Wyska E,Wlaź P

更新日期：2017-07-01 00:00:00

abstract：:Acrolein is a highly toxic, volatile, unsaturated aldehyde generated during incomplete combustion as in tobacco smoke and indoor fires. Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke-induced lung injury, we assessed its role in high-level acrolein-induced toxicity in mice. Ac...

journal_title：Toxicology and applied pharmacology

authors： Conklin DJ,Haberzettl P,Jagatheesan G,Kong M,Hoyle GW

更新日期：2017-06-01 00:00:00

abstract：:Steatosis is the characteristic type of VPA-induced hepatotoxicity and may result in life-threatening hepatic lesion. Approximately 61% of patients treated with VPA have been diagnosed with hepatic steatosis through ultrasound examination. However, the mechanisms underlying VPA-induced intracellular fat accumulation a...

journal_title：Toxicology and applied pharmacology

authors： Bai X,Hong W,Cai P,Chen Y,Xu C,Cao D,Yu W,Zhao Z,Huang M,Jin J

更新日期：2017-06-01 00:00:00

abstract：:Many studies of nanomaterials make non-systematic alterations of nanoparticle physicochemical properties. Given the immense size of the property space for nanomaterials, such approaches are not very useful in elucidating fundamental relationships between inherent physicochemical properties of these materials and their...

journal_title：Toxicology and applied pharmacology

authors： Bai X,Liu F,Liu Y,Li C,Wang S,Zhou H,Wang W,Zhu H,Winkler DA,Yan B

更新日期：2017-05-15 00:00:00

abstract：:Dendritic cells (DC) are known to play a major role during contact allergy induced by contact sensitizers (CS). Our previous studies showed that Nrf2 was induced in DC and controlled allergic skin inflammation in mice in response to chemicals. In this work, we raised the question of the role of Nrf2 in response to a s...

journal_title：Toxicology and applied pharmacology

authors： El Ali Z,Deloménie C,Botton J,Pallardy M,Kerdine-Römer S

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Atmospheric ultrafine particles (UFPs) and pesticide rotenone were considered as potential environmental risk factors for Parkinson's disease (PD). However, whether and how UFPs alone and in combination with rotenone affect the pathogenesis of PD remains largely unknown. METHODS:Ultrafine carbon black (ufCB...

journal_title：Toxicology and applied pharmacology

authors： Wang Y,Liu D,Zhang H,Wang Y,Wei L,Liu Y,Liao J,Gao HM,Zhou H

更新日期：2017-05-01 00:00:00

abstract：:Aconitine (AC) is the primary bioactive/toxic alkaloid in plants of the Aconitum species. Our previous study demonstrated that Mdr1 was involved in efflux of AC. However, the mechanism by which Mdr1 regulates the efficacy/toxicity of AC in vivo remains unclear. The present study aimed to determine the effects of Mdr1a...

journal_title：Toxicology and applied pharmacology

authors： Zhu L,Wu J,Zhao M,Song W,Qi X,Wang Y,Lu L,Liu Z

更新日期：2017-04-01 00:00:00

abstract：:Glycyrrhetinic acid (GA), the main active ingredient of licorice, reportedly has anti-inflammatory and hepatoprotective properties, but its molecular mechanisms remain be elusive. In the present study, Balb/c mice were pretreated with GA (10, 30, or 100mg/kg) 1h before lipopolysaccharide (LPS)/d-galactosamine (D-GalN)...

journal_title：Toxicology and applied pharmacology

authors： Yin X,Gong X,Zhang L,Jiang R,Kuang G,Wang B,Chen X,Wan J

更新日期：2017-04-01 00:00:00

abstract：:Glucocorticoid Receptor (GR) is present in virtually every human cell type. Representing a nuclear receptor superfamily, GR has several different isoforms essentially acting as ligand-dependent transcription factors, regulating glucocorticoid-responsive gene expression in both a positive and a negative manner. Althoug...

journal_title：Toxicology and applied pharmacology

authors： Gulliver LS

更新日期：2017-03-15 00:00:00

abstract：:Chemotherapy is one of the major strategies for cancer treatment. Several antineoplastic drugs including vinorelbine (VRB) are commonly intravenously infused and liable to cause serious phlebitis. The therapeutic drugs for preventing this complication are limited. In this study, the mechanism of baicalein (BCN) was in...

journal_title：Toxicology and applied pharmacology

authors： Ge GF,Shi WW,Yu CH,Jin XY,Zhang HH,Zhang WY,Wang LC,Yu B

更新日期：2017-03-01 00:00:00

abstract：:Early-life exposure to arsenic increases risk of developing a variety of non-malignant and malignant diseases. Arsenic-induced carcinogenesis may be mediated through epigenetic mechanisms and pathways leading to inflammation. Our previous study reported that prenatal arsenic exposure leads to increased mRNA expression...

journal_title：Toxicology and applied pharmacology

authors： Phookphan P,Navasumrit P,Waraprasit S,Promvijit J,Chaisatra K,Ngaotepprutaram T,Ruchirawat M

更新日期：2017-02-01 00:00:00

abstract：:Immobilization of nanoparticles on inorganic supports has been recently developed, resulting in the creation of nanocomposites. Concerning titanium dioxide nanoparticles (TiO2 NPs1), these have already been developed in conjugation with clays, but so far there are no available toxicological studies on these nanocompos...

journal_title：Toxicology and applied pharmacology

authors： Bessa MJ,Costa C,Reinosa J,Pereira C,Fraga S,Fernández J,Bañares MA,Teixeira JP

更新日期：2017-02-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant that activates the aryl hydrocarbon receptor (AhR) resulting in altered gene expression. In vivo, in vitro, and ex vivo studies have demonstrated that B cells are directly impaired by TCDD, and are a sensitive target as evidenced by sup...

journal_title：Toxicology and applied pharmacology

authors： Kovalova N,Nault R,Crawford R,Zacharewski TR,Kaminski NE

更新日期：2017-02-01 00:00:00

abstract：:Intravesical gemcitabine has recently been introduced for the treatment of superficial bladder cancer and has a favourable efficacy and toxicity profile in comparison to mitomycin c (MMC), the most commonly used chemotherapeutic agent. The aim of this study was to assess the cytotoxic potency of gemcitabine in compari...

journal_title：Toxicology and applied pharmacology

authors： Farr SE,Chess-Williams R,McDermott CM

更新日期：2017-02-01 00:00:00

abstract：:Chlorinated dibenzo-p-dioxins (CDDs) are a series of mono- to octa-chlorinated homologous chemicals commonly referred to as polychlorinated dioxins. One of the most potent, well-known, and persistent member of this family is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). As part of translational research to make computer...

journal_title：Toxicology and applied pharmacology

authors： Emond C,Ruiz P,Mumtaz M

更新日期：2017-01-15 00:00:00

abstract：:Combined exposure of cadmium (Cd) and insulin resistance (IR) might be responsible for subfertility. In the present study, we investigated the effects of Cd in vitro in IR human granulosa cells. Isolated human granulosa cells from control and polycystic ovary syndrome (PCOS) follicular fluid samples were confirmed for...

journal_title：Toxicology and applied pharmacology

authors： Belani M,Shah P,Banker M,Gupta S

更新日期：2016-12-15 00:00:00

abstract：:Staphylococcal enterotoxin C2 (SEC2), a member of bacterial superantigen, is one of the most potent known activators of T lymphocytes. With this property, SEC2 has already been used in clinic as a tumor immunotherapy agent in China. To increase the antitumor activity, a SEC2 mutant named ST-4 (GKVTG102-106WWH) with am...

journal_title：Toxicology and applied pharmacology

authors： Zhang G,Xu M,Zhang H,Song Y,Wang J,Zhang C

更新日期：2016-12-15 00:00:00

abstract：:MicroRNAs (miRNAs) are post-transcriptional regulators that silence messenger RNAs. Because miRNAs are stable at room temperature and long-lived, they have been proposed as molecular biomarkers to monitor disease and exposure status. While urinary miRNAs have been used clinically as potential diagnostic markers for ki...

journal_title：Toxicology and applied pharmacology

authors： Weldon BA,Shubin SP,Smith MN,Workman T,Artemenko A,Griffith WC,Thompson B,Faustman EM

更新日期：2016-12-01 00:00:00

abstract：:Human exposure to certain natural and man-made chemical carcinogens is one of the major risk factors for cancer development. The effect of chemical carcinogens on genetic and epigenetic alterations and their significance in the development of cancer has been well-established. In contrast, the role of microRNAs (miRNAs...

journal_title：Toxicology and applied pharmacology

authors： Pogribny IP,Beland FA,Rusyn I

更新日期：2016-12-01 00:00:00

abstract：:Triple-negative breast cancers (TNBCs) are highly invasive and have a higher rate of distant metastasis. Matrix metalloproteinase-9 (MMP-9) plays a crucial role in EGF/EGFR-mediated malignant progression and metastasis of TNBCs. Various studies have revealed that treatment with gallic acid down-regulates MMP-9 express...

journal_title：Toxicology and applied pharmacology

authors： Chen YJ,Lee YC,Huang CH,Chang LS

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Bleeding episodes commonly occur in patients on warfarin treatment even in those within therapeutic range of international normalized ratio (INR). The objective of this study was to investigate the effects of the 8 examined polymorphisms on the risk of bleeding complications in a sample of Iranian patients. ...

journal_title：Toxicology and applied pharmacology

authors： Pourgholi L,Goodarzynejad H,Mandegary A,Ziaee S,Talasaz AH,Jalali A,Boroumand M

更新日期：2016-10-15 00:00:00

abstract：:Triclosan (TCS) is an antimicrobial agent commonly found in a variety of personal care products and cosmetics. TCS readily enters the environment through wastewater and is detected in human plasma, urine, and breast milk due to its widespread use. Studies have implicated TCS as a disruptor of thyroid and estrogen sign...

journal_title：Toxicology and applied pharmacology

authors： Haggard DE,Noyes PD,Waters KM,Tanguay RL

更新日期：2016-10-01 00:00:00

abstract：:Thyroid homeostasis can be disturbed due to thiocyanate exposure from the diet or tobacco smoke. Thiocyanate inhibits both thyroidal uptake of iodide, via the sodium-iodide symporter (NIS), and thyroid hormone (TH) synthesis in the thyroid, via thyroid peroxidase (TPO), but the mode of action of thiocyanate is poorly ...

journal_title：Toxicology and applied pharmacology

authors： Willemin ME,Lumen A

更新日期：2016-09-15 00:00:00

abstract：:Carbendazim inhibits microtubule assembly, thus blocking mitosis and inhibiting cancer cell proliferation. Accordingly, carbendazim is being explored as an anticancer drug. Data show that carbendazim increased mRNA and protein expressions and promoter activity of CYP1A1. In addition, carbendazim activated transcriptio...

journal_title：Toxicology and applied pharmacology

authors： Wei KL,Chen FY,Lin CY,Gao GL,Kao WY,Yeh CH,Chen CR,Huang HC,Tsai WR,Jong KJ,Li WJ,Su JG

更新日期：2016-09-01 00:00:00